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Modern studies have reported that the protein-free Guang-Pheretima decoction (PF-GPD) can inhibit the release of inflammatory factors IL-1 and IL-6, regulate the homeostasis of microcirculation, and play an important role in the intervention of HACE pathology ( Pheretima aspergillum and its compound formulations can modulate neuroinflammation and microcirculatory dysfunction, offering a potential therapeutic strategy for mitigating oxidative damage in brain tissue, and restoring the BBB function under high-altitude hypoxic conditions

Some of the signals reflect detailed predictions about rewarding and aversive experiences, while others indicate fast responses to events of high potential importance

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Additionally, in-vivo distribution analysis of rat brains following intranasal administration revealed a higher fluorescence intensity in lactoferrin-modified nanoemulsions than in non-modified nanoemulsions because of the greater affinity for lactoferrin-expressing cells and transcytosis

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