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Tumor Cell Protection: Once malignant cells have developed, elevated glutathione within tumors can protect those cells from oxidative damage and reduce the effectiveness of certain chemotherapeutic agents

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Primarily, CHAC2 can inhibit tumor progression by decreasing cellular GSH levels and inducing mitochondrial apoptosis ( CHAC1 , CHAC2 expression varies significantly between tissues

Plant J 18:285292 Cummins I, OHagan D, Jablonkai I, Cole DJ, Hehn A, Werck-Reichhart D, Edwards R (2003) Cloning, characterization and regulation of a family of phi class glutathione transferases from wheat

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