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In addition, mtROS can also directly act on some proteins on the mitochondrial matrix or mitochondrial membrane, and regulate the activity of mitochondrial complex I, complex III, and complex IV through Toll-like receptors, retinoic acid-inducible gene I-like receptors and other signaling pathways, thereby affecting OXPHOS

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Patients were randomized 1:1 to use smartphone (two one-minute spot-checks daily) or smartwatch (semi-continuous measurements every nine minutes) for six months