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We connected the whole body model of acetaminophen metabolism to our previously constructed model of glutathione metabolism[9] so that we could study the depletion of GSH after APAP doses of various sizes (Figure6)

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De plus, le glutathion peut chlater les ions mtalliques (comme le cuivre), cofacteurs essentiels de la tyrosinase, contribuant ainsi un mcanisme d'claircissement cutan au niveau enzymatique

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3H) in the IIRI group were reversed by fecal treatment