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Prolonged calcium transients and myocardial remodelling in early experimental uraemia

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0.1% (placebo) Steady State: Achieved after 4-5 weeks of weekly dosing Safety: Nausea (68% at 4.5 mg), vomiting (32%), generally mild-moderate and transient Discontinuation: 14% discontinued due to GI adverse events Appetite Effects: Significant reductions in Visual Analogue Scale (VAS) hunger scores Publication: Lau DCW, et al

10.1002/jsfa.9997 121 LiangD.MinikesA

Wen RJ, Dong X, Zhuang HW, Pang FX, Ding SC, Li N, et al

Full functional recovery often requires the complete protocol duration even when subjective healing feels complete earlier