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This outcome was attributed to MOTS-c restoring metabolic balance in muscle tissue (largely via AMPK activation), underscoring its potential for combating age-dependent metabolic decline

[41] This trial's event-driven design and focus on high-risk patients underscored semaglutide's cardiovascular benefits, influencing regulatory decisions despite the retinopathy findings

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Mechanisms of action of GLP-1 in the pancreas

Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice