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Starting from week 2, stepwise administration resulted in greater body weight loss compared to vehicle and individual monotherapies

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Common gastrointestinal AEs include: Nausea: The most frequently reported adverse event, with an incidence of 44% in the semaglutide group compared to 18% in the placebo group during the STEP-1 trial

The study included 84 men ages 18-64 years old with opioid-induced testosterone deficiency

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