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531 In SLE models, rapamycin improves endothelial function and reduces inflammation with long-term efficacy and tolerability

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In addition, astrocytes, which normally support neurons, become dysfunctional through a process called astrogliosis, which worsens glutamate imbalance and reduces neuronal support (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy

Before you can use it, you must reconstitute it with bacteriostatic water to create an injectable solution

Diabetes Ther 2019;10:232130