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Women with PCOS are frequently overweight or obese and exhibit a greater abdominal circumference than women with isolated obesity

Upon crossing the BBB, the NPs release liraglutide, which targets neurons and glia, reduces neuroinflammation by suppressing NF-B signaling in microglia, and promotes astrocytic polarization toward a neuroprotective A2 phenotype [208, 273] ( Fig

Incidence is on the rise, driven in part by the close association of NAFLD with insulin resistance, diabetes, and obesity, all of which are increasing globally

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Therefore, early phenotype prediction is warranted, but this is complicated as most lcFAODs lack a clear genotype-phenotype correlation