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Nooshkam, M., Varidi, M

Some compounds have strong mechanistic logic but thin clinical evidence

The trial enrolled 445 adults with obesity and moderate-to-severe knee osteoarthritis pain (without diabetes), randomized 1:1:1 to 9mg, 12mg, or placebo over 68 weeks

As manufacturer pricing programs, insurance coverage, and potential government initiatives continue to evolve, the value proposition of compounded alternatives may shift over time

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