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Heres why shots work better: They skip the digestive system They release from the muscle They have a stronger effect on red blood cell production They provide better support for brain and nerve health Better retention is seen in people with a deficiency How to Tell If Your B12 Shot Is Wearing Off Recognizing when your shot is losing its effect can help you plan your next dose on time

Prolonged vitamin B12 deficiency can also lead to irreversible damage to the nervous system

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Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging

Overall, if you have enough vitamin B12 in your body, you should have an increased level of cognitive functioning, and energy, and are more likely to be in a good mood

At that 6-month follow-up, all signs and symptoms of EDS had been resolved