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Among the tissues and organs crucial in regulating glucose and lipid metabolism, pancreas, brain, and adipocytes express GIP receptors (GIPRs), while pancreas, brain, and gastrointestinal tract are rich in GLP-1 receptors (GLP-1Rs) ( The hormonal binding at the extracellular domain is communicated to the intracellular receptor side, leading to G protein engagement and activation ( 2.3 Interaction of GIP and GLP-1 in the incretin effect Studies in rodents ( Figure 1 Section A]

However, GLP-1 may also participate in regulating the function of RAAS

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Furthermore, IGF-1 increased extensor digitorum longus (EDL) and soleus muscle masses of dystrophic mice by 20% and 29%, respectively, as compared with untreated dystrophic controls [77]