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In addition to not being a non-randomized controlled trial, criticisms of the study include that the published data was not sufficient to establish a causal association between GLP-1 receptor agonist use and NAION
The most frequently reported symptoms include: Nausea (especially during dose increases) Vomiting Diarrhea Constipation Abdominal discomfort Decreased appetite (an expected effect of the medication) For most patients, side effects stay in the tolerable range and tend to taper off as treatment continues
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Prescribed as either a generic or under the brand name Contrave, which is a single pill FDA approved in 2014, its a combination of two medications: bupropion and naltrexone
However, NHS access is restricted by NICE Technology Appraisal 875 to specific patient cohorts
