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PlexusDx explains the connection and helps you distinguish medication effects from weight-loss adjustment

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Although low serum B12 levels have been associated with increased bone turnover and fracture risk (9) , long-term B12 and folic acid supplementation did not improve bone mineral density (38) , or reduce osteoporotic fracture incidence in elderly individuals with elevated plasma homocysteine levels (39)

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Some previous study has shown that the steady-state concentration level of lactate (i.e., the abnormal product of glycolysis) interacts with OA, and reducing lactate concentration dependence by inhibiting the glycolytic activity of OA can delay the progression of OA (136)

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