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While the medication itself doesn't directly form gallstones, its potent weight loss effects create conditions that increase gallbladder disease risk

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doi: 10.1136/gut.2008.165886 19 CejuelaM.Martin-CastilloB.MenendezJ

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Moreover, those treated with the exercise-only protocol maintained their weight loss more successfully (average 2.5 kg regained) than those with the GLP-1-only protocol (average 6.0 kg regained) (Jensen, 2024)