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UVR-induced DNA damage and alterations in the extracellular matrix (ECM) disrupt homeostasis and trigger cellular stress, leading to the activation of inflammatory responses in the skin as shown in Figure 2

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On the other hand, various chemicals have been shown to be activated into potentially dangerous compounds by these enzymes (Sherratt et al., 1997)

There are various potential causes of vitamin B12 deficiency besides pernicious anemia, which gastrointestinal surgery long-term use of certain medications, such as proton pump inhibitors genetic intrinsic factor defects dietary deficiency Pernicious anemia requires lifelong treatment

Mol Cancer Res 21:675690