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The cumulative incidence was 6.7% for GLP-1 compared to 0.8% for non-GLP-1 RA over 36 months, with a hazard ratio (HR) of 7.64 (95% CI, 2.21-26.36

[3] [8] However, important considerations exist

[115] It appears that fundamental breakthroughs on organ-organ communications are needed in this area before we can advance our understanding on the anorectic effect and other brain functions of peripherally administrated GLP-1RAs