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10.1016/j.vph.2014.08.005 42 Keyvani-GhamsariS.RahimiM.KhorsandiK

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During molecular dynamic simulations with GLP-1 bound, the N-terminal helix was oriented vertically (black and blue arrows), whereas in the apo-form the ECD N-terminal helix was more dynamic and experienced both open and closed conformations (this is analogous to the suggested ECD dynamics for the glucagon receptor)