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In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

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Age, amount of physical activity, and other lifestyle factors influence the bodys capacity to absorb essential nutrients from our diet

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The head-to-head SURMOUNT-5 data leaves no room for debate: tirzepatide outperforms semaglutide for weight loss in the same patient population