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Oral semaglutide can be used as a treatment intensification option even in addition to insulin.[21] PIONEER 5 was a randomized, double-blind, placebo-controlled, parallel-group, multicentre, multinational trial that included 324 subjects with T2DM and estimated glomerular filtration rate (eGFR) 3059 mL/min/1.73 m 2 , on stable doses of 12 oral antidiabetic drugs (OADs) (metformin, SU) and/or basal insulin for 90 days randomized to oral semaglutide 14 mg and placebo (1:1)

Semaglutide (marketed under the brand name Wegovy) and liraglutide (Saxenda) did lead to weight loss, but it was significantly less at 15% and 8%, respectively

Available from: Authorship Authored by Hannah Morgan Content Writer Hannah Morgan is a content writer at Simple Online Pharmacy

The research team noted that the reduction in body weight was not related to any nausea or vomiting reported by the patients [2]

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Injection site reactions are relatively common, affecting anywhere from 0.5% to 40% of users