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Tirzepatide was associated with a lower risk of ED compared to every medication it was tested against

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The insulin sensitivity advantage for tirzepatide is larger than weight loss alone explains (Diabetes, Obesity and Metabolism, 2025), which suggests the GIP component does real metabolic work beyond appetite suppression

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JAMA Network Another large observational study found that people with T2DM and obesity using semaglutide or tirzepatide had lower risk of dementia, stroke, and all-cause mortality compared to those on other glucoselowering agents

Because appetite can drop so sharply, some people unintentionally under-eat