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Immune resistant melanoma cell clones that have survived are able to proliferate and migrate to distant organs without immune detection, a term coined as the escape phase (61)

For example, triple-ligand systems have demonstrated: These systems often combine different mechanisms such as amino acids, peptides, and metabolic ligands to optimize uptake

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Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

Studies suggest it may support cellular longevity, enhance immune function, regulate circadian rhythms, and influence various cellular processes related to aging