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The possibility of different conformations was considered for all structures

Tirzepatide works by mimicking the action of two naturally occurring hormones in the body, GIP and GLP-1. Both of these hormones are involved in regulating blood sugar levels

PIH results from stimulation of melanocytes and overproduction of melanin in the epidermis in response to cytokines, chemokines released during inflammation

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This supports our observation that the presence of positive/polar charged residues at this position interacting with negatively charged phosphorylation sites in the R-domain is important for proper functioning of this family of transporters (Supplementary Fig