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In addition, Methylcobalamin Injections are used worldwide to treat peripheral neuropathy, diabetic neuropathy, and amyotrophic lateral sclerosis (ALS)

Tirzepatide (Zepbound) goes a step further: it activates the GLP-1 receptor and also a second incretin receptor called GIP , which is why it is described as a dual agonist, and it is also weekly

120 An unexpected phenotype produced by GIPR deficient ob/ob mice was that they lost weight by increasing their energy expenditure, which is surprising as their insulin levels were not significantly altered in comparison to control mice, and therefore their energy expenditure should have been similar to control mice

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These suggest that the delivery of IGF-1 through an engineered exosome system is a valuable research direction