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Insulin lowers blood sugar levels by removing glucose from the blood and taking it to body tissues for energy and energy storage

16,17 Thus, the activity of the pancreatic islets and the L and K cells are closely coupled to maintain metabolic homeostasis in humans

Metformin is a biguanide drug used as the FIRST-LINE treatment for Type 2 Diabetes Mellitus (T2DM)

Per Giblin et al

The mean age of GLP-1RA and DPP-4i users was 58.7 years, with standard deviations of 11.4 and 12.1, respectively (standardized mean difference [SMD] = 0.0033)