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nevertheless, their most pronounced effect in obesity is appetite reduction through central nervous system (CNS) mechanisms, mainly within the hypothalamus [35]
Early studies show improvements in brain glucose metabolism, reduced inflammation, and protection of neurons from degeneration
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Additionally, secondary BAs exhibit strong antimicrobial activity (93, 94), and exert protective effects on gout by suppressing inflammatory responses through TGR5-mediated downregulation of the NF-B signaling pathway (101)
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