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There have been reports of a number of changes in the concentrations of several neuropeptides in PD brain, which are mainly significant decreases in (Jimnez-Jimnez, 1994): (a) met-enkephalin (MET-ENK), substantia P (SP), and cholecystokinine 8 (CCK-8) in the substantia nigra

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J., Wang, M

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Genetic influences on ratios of interacting metabolite pairs change during SSRI treatment To identify potential modulators of significant metabolitemetabolite interactions and their differential interactions over time, we performed genome-wide association studies with the pairwise ratios of HGA/GR and MET/TYR in 288 subjects at each time point