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For example, accumulation of lipid hydroperoxides [80], and increased oxidative DNA damage accompanied by reduced levels of SOD [79] were observed in the brain of autistic individuals

Delayed gastric emptying (e.g., opioids, gastroparesis)

This dual mechanism provides enhanced effects on blood sugar control and weight loss compared to single-pathway GLP-1 agonists like semaglutide or liraglutide

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These substances affect not only opioid receptors but may also influence serotonin and dopamine systems, contributing to prolonged withdrawal and ongoing cravings