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Therefore, we believe the one-time burden estimate to implement the new requirements finalized in this final rule with comment period to be 88,992 hours for all hospitals (12 hours 7,416 hospitals) at a cost of $10,840,708.80 (7,416 hospitals [($87.52 8 hours) + ($128.00 2 hours) + ($252.82 2 hours])

The methylation cycle supports functions such as: DNA synthesis Nervous system function Myelin production Homocysteine metabolism When vitamin B12 or folate levels are low, the body may have difficulty producing healthy red blood cells, which may contribute to macrocytic anemia

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