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a patient on insulin or sulfonylureas might experience lower blood sugars once berberine is added, so glucose should be monitored and diabetes medications adjusted to avoid hypoglycemia

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doi: 10.1056/NEJMoa1612917 23 HondaJ.KimuraT.SakaiS.MaruyamaH.TajiriK.MurakoshiN.et al

JTCVS Open 29, 2026

We will discuss the life-sustaining importance of GSH, its relationship with oxidative stress, as well as its synthesis and catabolism, its biological functions and the paramount relevance of GSH in the immune system (especially the innate immune system), in reducing COVID-19 severity and mortality, and the antiviral capabilities of GSH to reduce SARS-CoV-2 infectivity and multiorgan failure secondary to a cytokine storm in COVID-19 disease