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Rate constants for mammalian glutaredoxins and poplar GrxS12 range from 2.5 10 4 to 2 10 6 M 1 s 1 and also support a rate-limiting reductive half-reaction 19,20,21,37

Its approved status is reflected in the ChEMBL registry at maximum phase 4

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Across Phase 2 and early Phase 3 trials, the compound has demonstrated weight reduction, glycaemic improvement, and liver fat resolution at levels exceeding previously approved GLP-1 and dual GIP/GLP-1 agonists

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