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RT-PCR analysis HCT116 dTAG-SNIP1 cells and its derivative stable cell lines expressing F-SNIP1 variants (WT, K265G, K265GK301G and E366G) were treated for 2 h with DMSO or 500 nM dTAG-V1

doi: 10.1152/jappl.1999.87.1.438

Cell death signaling

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One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Sharma et al., 2010)