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The FDA approval of the first oral GLP-1 for weight loss in December 2025-Novo Nordisk's once-daily semaglutide pill-represents a watershed moment for the category [3]

These central effects translate into substantial weight loss - typically 5%-15% of body weight with current GLP-1 RAs - which directly ameliorates hepatic steatosis by reducing adipose tissue mass, reducing hepatic free fatty acid influx, and improving insulin sensitivity