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Concomitant medications also matterOzempic works synergistically with metformin and may be combined with SGLT2 inhibitors or insulin, potentially enhancing overall HbA1c reduction

A brief on how retatrutide works Retatrutide is an investigational once-weekly injectable that activates three hormone receptor systems at once, GLP-1, GIP, and glucagon, which slows digestion, improves insulin response, and directly promotes fat burning

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Most patients tolerate long-term use well, especially with medical guidance