why do you lose muscle on semaglutide Weight loss and loss. The facts. GLP-1 drugs like and tirzepatide produce impressive weight loss — but a consistent and underappreciated finding across trials is that a meaningful proportion of Losing weight on a GLP-1?

A clear liquid diet may be recommended for 2 to 3 days

Key Takeaways for Providers Semaglutide alone: About 35% of weight lost is lean mass, which may undermine functional outcomes

It is not FDA-approved for weight loss

In severe cases, it can cause high fever, seizures, irregular heartbeat, and loss of consciousnessseek immediate medical attention by calling 999 if you experience these symptoms

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The SURPASS and SURMOUNT trials showed tirzepatide producing greater average weight loss than semaglutide over the full treatment period, but both medications produced clinically significant results