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Studies have looked at AHK-Cu's interaction with Wnt signalling, a cellular pathway involved in hair follicle development and cycling

For patients requiring no dialysis, restricting protein intake to 0.8 g/kg per day is appropriate since this level slows the reduction in eGFR while higher or lower level showed no better or even worse effect

Topiramate has also been studied but is not licensed for BED in the UK and carries significant side effect concerns including cognitive impairment and paraesthesia

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It may cause a decrease in alertness and mental capacity

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