glp 1 ckd benefit Can one drug do it all? Reviewing the expanding clinical universe of GLP-1 agonists GLP-1 Use in Non-Diabetics Associated

In intact murine islets, blockade of N-type Ca 2+ channels with -conotoxin, but not L-type Ca 2+ channels using nifedipine, abolishes low glucose (1 mM) stimulation of glucagon secretion and blunts the GLP-1-mediated inhibitor effects

Clinically, the effect is unmistakable

The manuscript is read and approved by all the authors

doi: 10.1136/bmjopen-2015-008203 109 MullerCCheungNWDeweyHChurilovLMiddletonSThijsVet al

Acting as an MC4R agonist, it has been shown to promote satiety, reduce caloric intake, and support weight loss

A recent study found that gut bacterial metabolite, Ruminococcaceae isoamylamine (IAA), which is enriched in older adults and aged mice, promotes age-related cognitive dysfunction by promoting microglial cell death (Teng et al., 2022)