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As in the LEAN study, the primary outcome is histologic resolution of NASH without worsening of fibrosis after 72 weeks of treatment, while secondary outcomes include improvement in liver fibrosis (1 stage) with no worsening of NASH, NAFLD activity score, as well as multiple serum markers of fibrosis

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Patient Eligibility Before starting treatment, patients must complete a medical consultation, share their medical history, discuss any current medications, and undergo initial blood tests

They also inhibit biofilm formation, modulate the inflammatory response, and promote wound healing in gingival tissue, making them multifunctional oral health agents

Patients with severe obesity will have access to the treatments through Medicare with a $50 co-pay starting as soon as mid-2026, the companies said

The appetite-suppression timeline and mechanism are identical