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Hyperglycemia decreases G6PD activity through the activation of protein kinase A (PKA) and increase of intracellular oxidative stress, leading to chronic kidney injury, and diabetic kidney disease (DKD) (4345)

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5.1 Oxidative regulation of intracellular signaling pathways Redox-regulated signaling pathways often operate through the reversible oxidation of specific cysteine residues within proteins

This low efficacy may be due to the poor solubility of hydrophobic CPPs 61

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