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APAP administration increases ROS in the drosophila fat body and depletes systemic glutathione In the mammalian liver, APAP is bio-converted into the toxic metabolite NAPQI by the Cytochrome P450 enzyme CYP2E1 4

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The lipid profile showed a significant reduction in triglycerides, total cholesterol, and lipoprotein compared to the control group 7

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There were indications of enhanced mitochondrial membrane potential and increased mtDNA copy numbers, suggesting that Epithalon might support mitochondrial integrity and functionality as oocytes age