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Image Credit: lucigerma / Shutterstock.com Introduction This article summarizes how oral glucagon-like peptide-1 (GLP-1) receptor agonists address weight-loss challenges, improve absorption, and enhance tolerability, as well as the promising future of GLP-1/glucose-dependent insulinotropic polypeptide (GIP) dual therapies

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Although Mounjaro, Ozempic, and Rybelsus are not FDA-approved for obesity treatment, they are included in the analysis due to the high number of patients with an obesity diagnosis using these products compared to other FDA-approved diabetes GLP-1 agonists

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It has an elimination half-life of approximately 38 h and is primarily cleared by hepatic metabolism to inactive metabolites