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For example, in breast cancer (BC) patients, HMGB1 expression serves as an effective indicator of the immunogenicity and efficacy of chemotherapeutic agents, and elevated levels of HMGB1 have been associated with improved clinical outcomes in patients receiving neoadjuvant chemotherapy [305]

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A prospective observational study in over 4,000 participants of the Framingham Heart Study and the Framingham Offspring Study with or without preexisting cardiovascular disease found no statistically significant association between vitamin E supplement intake and cardiovascular or all-cause mortality after a 10-year follow-up period (124)

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