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These metrics include physiological (for example, stress hormone levels, microbial metabolites, measures of barrier function and immune parameters) and psychological readouts (for example, perceived stress)

The functional nature of F45 workouts ensures that exercises mimic everyday movements, enhancing functional strength and reducing the risk of injury

To test this directly, we performed hyperinsulinemic-euglycemic clamp studies (Supplemental Figure 1P)

Additional studies will be required to determine whether metformin can increase incretin receptor expression in human beta cells and thereby bolster incretin action in a meaningful way