"Some people are deficient and feel a lot better when given a shot, but just to pep you up, there's no study that says it's helpful." B12 is created by bacteria, including those living in the digestive tract
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in total, 9 genera (including the unclassified group) and 38 metabolites met these criteria (metabolites published in Sampson et al., 2021 13 )
That question originated in an Australian university laboratory, was carried into a commercial development program with a stabilized analogue, tested in a series of controlled human trials, and ultimately routed away from drug registration and toward a US dietary-ingredient determination
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Yes, all meals are included from lunch on day 1 to breakfast on day 6