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International Journal of Molecular Sciences, 20(17), 4294

Grice, G

Worryingly however, 26.8% of patients had to discontinue the trial due to the severity of side-effects, although it must be noted that this was in part due to the lack of a run-in (A time frame where drug dosage is started from a low dosage and then escalated over time until the highest tolerable dose for the patient is reached) [40]

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S., Salinsky, M

They also promote NO production, which is required for cell death induction ( Arabidopsis PCD by promoting MPK6-mediated caspase-3-like activation (Ye et al., 2013)