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Semaglutide does not directly affect testosterone production or absorption

As an example, for the person who initiated at 200 pounds, lost 10 pounds at the time of discontinuation (5% reduction in weight), a regain of 6 pounds since stopping (3% increase in weight) was associated with an 8% higher likelihood of restarting, compared to someone who did not regain any weight

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Palacios et al, 2010