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Significantly, a compound denoted as melatonin-trientine, covalently synthesized with melatonin and the metal ion chelator trientine, demonstrated the capacity to elevate the expression of IDE in a murine AD model, and decreased A deposition and neuronal degeneration in the brains of the APP/Presenilin 1 mice [65]

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Fujita N, Aishima S, Iguchi T, Mano Y, Taketomi A, Shirabe K, et al

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