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At 15mg per serving of Paradoxine standardized to 12.5% 6-paradol, Fireball includes Grains of Paradise at a thermogenically relevant dose the noticeable heat sensation users report is a direct result of BAT activation and the systemic thermogenesis it produces.

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Sheehan D, Meade G, Foley V, Dowd C (2001) Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily