doi: 10.3389/fendo.2022.824215 39 StrattonIMHolmanRRBoultonAJ
The main mechanism of action of these GLP-1RA is the stimulation of the GLP-1R that triggers the activation of several metabolic pathways involved in insulin secretion, lipid metabolism, energy expenditure, pro-survival and anti-apoptotic cellular signaling, and oxidative stress prevention, in several tissues like the pancreas, central nervous system, heart, muscle, kidneys, gut, among others (15)
Cognitive disorders Pre-clinical and mechanistic studies Our search retrieved a high number ( N = 189) of pre-clinical or mechanistic studies assessing the possible effects of GLP-1RAs on cognitive disorders, which cannot be described in the main text of this article due to space constraints (Supplementary Section 4)
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The GLP-1 agonists drugs market report also covers current unmet needs and challenges while incorporating new classes in treatment paradigm, variations in accessibility and acceptability of new Glucagon-like Peptide-1 (GLP-1) Agonists in different geographies, along with insights on Glucagon-like Peptide-1 (GLP-1) Agonists pricing reimbursements to curate the best opportunities and assess the markets potential
Emerging research has also linked long-term GLP-1 use to an elevated risk of vision problems
