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(2018) found that the natural polyphenol chlorogenic acid is protective against APAP-induced hepatotoxicity through activation of Nrf2 antioxidant signalling pathway by blocking the binding of Nrf2 to Keap1

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However, once the capacity of MTs to store Cd is exceeded, the latter, in its free form, induces the formation of anti-MTs, which are also toxic to the PCT cells

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Neurology 93 , e200e209 (2019)